R-Spondin-2 stands for roof plate-specific spondin-2. Human R-Spondin-2 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human R-Spondin 2

Overview

R-Spondin-2 stands for roof plate-specific spondin-2. Human R-Spondin-2 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human R-Spondin-2 can be used for a variety of applications including:
  • Stimulation of adult stem cell proliferation in vitro and in vivo.
  • Investigation of embryonic development and tissue differentiation.
  • Study of the canonical Wnt/β-catenin signaling pathway.

Detailed product information

Background information

R-Spondin-2, also known as Rspo-2, is a growth factor belonging to the R-Spondin family. R-Spondins are four proteins that support adult stem cell proliferation, and act as Wnt modulators by signaling through the canonical Wnt/β-catenin pathway as agonists. LGR4, LGR5, and LGR6 have been identified as receptors for all four R-Spondins. R-Spondin-2 is expressed in endoderm-derived tissues and is an agonist of Wnt-3a signaling and an inhibitor of DKK-1, Activins, and BMP-4. It plays an important role in morphogenesis of respiratory tract and limbs, and induces cell proliferation of the gastrointestinal tissues.

Biological activity

  • Differentiation of MC3T3-E1 cells in presence of BMP-2
  • research grade: ≥ 0.5×
    10
    3
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human R-Spondin 2

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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