Recombinant human IL-21 (interleukin 21) can promote Th17 or Tfh differentiation of T cells, expansion of CD8+ T cells, as well as B and NK cell development. Thus, the pleiotropic cytokine regulates several aspects of lymphoid cell function and has central roles for humoral immunity. IL-21 has been associated with allergies, cancer, and viral infections. Recombinant protein human IL-21 was developed for use in various applications, such as cell culture, differentiation studies, and functional assays.

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