Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
MHC class I HLA-A2

Extended validation for HLA-A2 Antibody, anti-human, REAfinity™


Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA517
Cells were incubated with an excess of purified unconjugated HLA-A2 (REA517) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for HLA-A2 Antibody, anti-human, REAfinity™


Clone REA517 recognizes the class I human leukocyte antigen A2 (HLA-A2). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and a soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA517 displays negligible binding to Fc receptors.

Alternative names

MHC class I HLA-A2

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenMHC class I HLA-A2
Molecular mass of antigen [kDa]38
Distribution of antigenother
Entrez Gene ID3105
RRIDAB_2751591, AB_2727641, AB_2727568, AB_2751639, AB_2751593, AB_2784362, AB_2784361, AB_2811492, AB_2811481, AB_2857613, AB_2857601, AB_2905232, AB_2905231, AB_2751637

Resources for HLA-A2 Antibody, anti-human, REAfinity™


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References for HLA-A2 Antibody, anti-human, REAfinity™


  1. Bjorkman, P. J. et al. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329(6139): 506-512
  2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
  3. Smith, S. N. et al. (2013) Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J. Mol. Biol. 425(22): 4496-4507

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