Clone:
REA162
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, ICFC
Alternative names:
GZMA, CTLA-3, HFSP, Granzyme 1

Specifications for Granzyme A Antibody, anti-human, REAfinity™

Overview

Clone REA162 recognizes granzyme A, a member of serine protease family expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells. Granzyme A is a homodimeric protease and is one of the five granzymes expressed by humans. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. NK cells and γδ T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells. Granzymes other than granzyme B, exert relatively weaker apoptotic activity. Additional reported functions of granzyme A include, to facilitate the migration of T and NK cells and induction of cytokine secretion.
Additional information: Clone REA162 displays negligible binding to Fc receptors.

Alternative names

GZMA, CTLA-3, HFSP, Granzyme 1

Detailed product information

Technical specifications

CloneREA162
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenGranzyme A
Alternative names of antigenGZMA, CTLA-3, HFSP, Granzyme 1
Molecular mass of antigen [kDa]26
Distribution of antigenT cells, NK cells
Entrez Gene ID3001
RRIDAB_2651901

Resources for Granzyme A Antibody, anti-human, REAfinity™

References for Granzyme A Antibody, anti-human, REAfinity™

Publications

  1. Grossman, W. J. et al. (2004) Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104: 2840-2848
  2. Müllbacher, A. et al. (1999) Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. U.S.A. 96(13): 13950 -13955
  3. Trapani, J. A. (2001) Granzymes: a family of lymphocyte granule serine proteases. Genome Biol. 2(12): 3014.1-3014.7

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