Clone:
REA1134
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
DES

Specifications for Desmin Antibody, anti-human, REAfinity™

Overview

Clone REA1134 recognizes the human Desmin, a muscle-specific type III intermediate filament, which is found in cardiac muscle, skeletal muscle and smooth muscle tissue. Desmin is essential for proper muscular structure and function and plays an important role in regulating the sarcomere architecture and integrating sarcolemma, Z disk, and nuclear membrane in sarcomeres.
Clone REA1134 does not react with Keratin, Vimentin and Neurofilament and GFAP.
Additional information: Clone REA1134 displays negligible binding to Fc receptors.

Alternative names

DES

Detailed product information

Technical specifications

CloneREA1134
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenDesmin
Alternative names of antigenDES
Molecular mass of antigen [kDa]54
Distribution of antigencardiac muscle, skeletal muscle, smooth muscle
Entrez Gene ID1674
RRIDAB_2857461, AB_2857462, AB_2857460

References for Desmin Antibody, anti-human, REAfinity™

Publications

  1. Debus, E. et al. (1983) Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein. EMBO J. 2(12): 2305-2312
  2. Altmannsberger, S. et al. (1985) Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am. J. Pathol. 118(1): 85-95
  3. Li, Z. et al. (1997) Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle. J. Biol. Chem. 139(1): 129-144

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