Clone REAL1149 is an antibody fragment derived from the full Cytokeratin 18 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1149 specifically recognizes cytokeratin 18 (K18). Cytokeratins are located in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratin 18 is frequently used in conjunction with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells and to enumerate circulating tumor cells in blood. Gene mutations of Keratin 18 lead in cryptogenic cirrhosis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
