CD137 (4-1BB) is expressed on activated CD4
+
and CD8
+
T cells, activated B cells, and natural killer cells, and can also be found on resting monocytes and dendritic cells. As a costimulatory molecule it is involved in the activation and survival of CD4
+
and CD8
+
T cells, and NK cells. CD137 has been described to be a suitable marker for antigen-specific activation of human CD8
+
T cells, as CD137 is not expressed on resting CD8
+
T cells and its expression is reliably induced after 24 hours of stimulation.
1
The CliniMACS CD137 Product Line consists of murine anti-CD137 monoclonal antibodies conjugated to biotin.

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