Clone:
REAL1033
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Chromogranin-A, CgA, CHGA

Specifications for Chromogranin A Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1033 is an antibody fragment derived from the full Chromogranin A antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity
Clone REAL1033 recognizes Chromogranin A, also known as parathyroid secretory protein 1, CHGA or CgA. Chromogranin A is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It functions as a precursor of different peptides such as vasostatin 1 and 2, catestatin, pancreastatin or parastatin and modulates the formation of secretory vesicles. It is detected in secretory vesicles of neurons and in several endocrine tissues including the adrenal medulla, pituitary, paraganglia, beta cells of pancreas, thyroid, and parathyroid. It is used as a marker for carcinoid tumors, insulinoma, pheochromocytomas, medullary thyroid carcinoma, paragangliomas, neuroblastoma and other neuro-endocrine tumors. Increasing Chromogranin A levels can also lead to non-malignant diseases such as gastrointestinal, cardiovascular and inflammatory diseases.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Chromogranin-A, CgA, CHGA

Detailed product information

Technical specifications

CloneREAL1033
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivitynon-human primate
AntigenChromogranin A
Alternative names of antigenChromogranin-A, CgA, CHGA
Distribution of antigenneurons, tumor cells, pancreas
RRIDAB_2905165

Resources for Chromogranin A Antibody, anti-human, REAdye_lease™

Certificates

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References for Chromogranin A Antibody, anti-human, REAdye_lease™

Publications

  1. Fischer-Colbrie, R. et al. (1985) Immunological studies on the distribution of chromogranin A and B in endocrine and nervous tissues . Neuroscience 16(3): 547-555
  2. Cotesta, D. et al. (2005) High plasma levels of human chromogranin A and adrenomedullin in patients with pheochromocytoma. Tumori 91(1): 53-58
  3. Lyubimova, N. V. et al. (2016) Chromogranin As a Biochemical Marker of Neuroendocrine Tumors. Bull Exp Biol Med 160(5): 702-704
  4. Raoof , M. et al. (2019) Prognostic significance of Chromogranin A in small pancreatic neuroendocrine tumors. Surgery 165(4): 760-766
  5. Mahata, S. K. et al. (2019) Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation. Ann. N. Y. Acad. Sci. 1455(1): 34-58

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