Anti-IgD antibodies

Anti-IgD antibodies

Clone: IgD26
IgD26 recognizes human IgD, a monomeric antibody with two heavy chains of the δ class and two Ig light chains. It is expressed by B cells and co-expressed with IgM on the surface of mature and naive B cells. It is also produced in a secreted form that is found in very small amounts in blood serum.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of IgD may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative names

IGHD

Technical specifications

  • Antigen: IgD
  • Clone: IgD26
  • Isotype: mouse IgG1κ
  • Alternative names of antigen: IGHD
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, VioBlue, FITC
  • Selected references

    1. Geisler, C. H. et al. (1991) Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia. Blood 78: 1795-1802
    2. Stelzer GT et al. (1997) U.S.-Canadian consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: standardization and validation of laboratory procedures. Cytometry 30(5): 214-230
    3. Gandini, D. et al. (1993) Immunophenotypic and genotypic characterization of B-cell chronic lymphocytic leukemia patients from Northern Italy. Haematologica 78: 18-24
    4. Rothe, G et al. (2012) Consensus protocol for the flow cytometric Immunophenotyping of hematopoietic malignancies. Leukemia 10(5): 877-895
    5. McMichael, A.J. et al. (1987) Leucocyte typing III. White cell differentiation Antigens. Oxford, Oxford University Press : 91
    6. Shen, P. U. et al. (2001) Laboratory, morphologic, and immunophenotypic correlates of surface immunoglobulin heavy chain isotype expression in B-cell chronic lymphocytic leukemia. Am. J. Clin. Pathol. 116(6): 905-912
    7. Cartron, G. et al. (1998) CD5 negative B-cell chronic lymphocytic leukemia: clinical and biological features of 42 cases. Leuk. Lymphoma 31: 209-216
    8. Clinical and Laboratory Standards Institute (CLSI) (2007) Clinical Flow Cytometric Analysis of Neoplastic Hematolympoid Cells, CLSI document H43-A2 (ISBN 1-56238-635-2) CLSI; Approved Guideline - Second Edition
    9. Clinical and Laboratory Standards Institute (CLSI) (2007) Enumeration of immunologically defined cell populations by flow cytometry, CLSI document H42-A2 (ISBN 1-56238-640-9) CLSI; Approved Guideline - Second Edition
    10. Batata, A. et al. (1992) Immunophenotyping of subtypes of B-chronic (mature) lymphoid leukemia. A study of 242 cases. Cancer 70: 2436-2443
    11. van Dongen, J. J. M. et al. (1996) Immunobiology of leukemia WB Saunders Company : 83-130
  • Brochures and posters

  • Certificates

    Please follow this
    link
    to download the Certificate of Conformity (CoC) by lot number.
Product options: 3
170-078-068

Anti-IgD-FITC

for 100
tests
EUR  385,00
170-078-069

Anti-IgD-APC

for 100
tests
EUR  460,00
170-078-067

Anti-IgD-VioBlue

for 100
tests
EUR  475,00