Clone:
REA1071
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
5H9, MRP-1, Tetraspanin-29 (Tspan-29), TSPAN-29, p24, MIC3, Tspan29, ORF, GIG2

Specifications for CD9 Antibody, anti-human, REAfinity™

Overview

Clone REA1071 recognizes the human CD9 antigen, a 25 kDa cell surface glycoprotein which is also known as tetraspanin-29 (Tspan-29). CD9 belongs to the tetraspanin family of integral proteins, which are characterized by the presence of four conserved transmembrane domains, a small and two large extracellular loops. Expression of CD9 is found on platelets, pre–B cells, fibroblasts, eosinophils, macrophages, basophils, epithelial cells, oocytes, and activated T cells. Further expression is reported on malignant cells and tumor cell lines where CD9 is involved in supressor functions, inhibition of cell invasion and metastasis. CD9 associates with other tetraspanin members, cell adhesion molecules such as EpCAM, integrin subsets, transmembrane proteins (EWI-2 and EWI-F), choline receptors, and G-proteins. Through diverse interactions or via direct stimulation, CD9 influences various cellular functions including cell adhesion, aggregation, migration, clustering of MHC molecules in dendritic cells (DCs), and provides costimulatory signal during T cell activation.
Additional information: Clone REA1071 displays negligible binding to Fc receptors.

Alternative names

5H9, MRP-1, Tetraspanin-29 (Tspan-29), TSPAN-29, p24, MIC3, Tspan29, ORF, GIG2

Detailed product information

Technical specifications

CloneREA1071
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD9
Alternative names of antigen5H9, MRP-1, Tetraspanin-29 (Tspan-29), TSPAN-29, p24, MIC3, Tspan29, ORF, GIG2
Molecular mass of antigen [kDa]25
Distribution of antigenB cells, epithelial cells, fibroblasts, granulocytes, macrophages, platelets, T cells, eosinophils, pre B cells, tumor
Entrez Gene ID928
RRIDAB_2733658, AB_2733844, AB_2733845, AB_2733405, AB_2733406, AB_2733954, AB_2733955, AB_2734094, AB_2734095, AB_2732986, AB_2732987, AB_2733252, AB_2733253, AB_2733145, AB_2733146, AB_2733043, AB_2733044, AB_2733538, AB_2733539, AB_2733657

Resources for CD9 Antibody, anti-human, REAfinity™

References for CD9 Antibody, anti-human, REAfinity™

Publications

  1. Hemler, M. E. (2003) Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 19: 397-342
  2. Jones, E. L. et al. (2011) Tetraspanins in cellular immunity. Biochem. Soc. T. 39(2): 506-511
  3. Wang, H. X. et al. (2011) The C-terminal tail of tetraspanin protein CD9 contributes to its function and molecular organization. Cell. Sci. 124: 2702-2710

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