Clone:
S5/1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC, MICS, IHC, IF
Alternative names:
C5AR1, C5A, C5AR, C5R1

Specifications for CD88 (C5AR) Antibody, anti-human

Overview

Clone S5/1 recognizes the human CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 expression is originally described on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on astrocytes, microglia, and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.

Alternative names

C5AR1, C5A, C5AR, C5R1

Detailed product information

Technical specifications

CloneS5/1
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
Cross-reactivityrabbit, ferret, bovine
AntigenCD88 (C5AR)
Alternative names of antigenC5AR1, C5A, C5AR, C5R1
Molecular mass of antigen [kDa]39
Distribution of antigenendothelial cells, epithelial cells, macrophages, monocytes, neutrophils
Entrez Gene ID728
RRIDAB_2659430, AB_2659431, AB_2659432, AB_2659433, AB_2659434, AB_2659435, AB_2659436, AB_2659437, AB_2659438, AB_2659439, AB_2659440, AB_2659441

Resources for CD88 (C5AR) Antibody, anti-human

References for CD88 (C5AR) Antibody, anti-human

Publications

  1. Gerard, N. P. et al. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349(6310): 614-617
  2. Farzan, M. et al. (2001) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193(9): 1059-1066
  3. Buck, E. et al. (2005) Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102: 2719-2724

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