Clone:
REA998
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
LILRB1, ILT2, LIR-1, MIR-7

Specifications for CD85j (ILT2) Antibody, anti-human, REAfinity™

Overview

Clone REA998 recognizes the human CD85j (ILT2) antigen, an inhibitory immunoreceptor of the immunoglobulin-like transcript (ILT) family. CD85j is a type I transmembrane protein with four extracellular Ig-like domains and four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail. The inhibitory signal is transmitted by recruiting SH2-containing protein tyrosine phosphatase-1 that dephosphorylates and inactivates downstream tyrosine kinases. Expression of CD85j is found on B cells, monocytes, dendritic cells, and subsets of natural killer (NK) and T cells. CD85j is known to bind classical and non-classical MHC class I molecules, human cytomegalovirus UL18 protein, and some HLA-C alleles, as ligands. Crosslinking of CD85j prevents activation of B cells, T cells, NK cells, macrophages, and downregulation of effector mechanisms, such as NK and T cells cytolytic functions.
Additional information: Clone REA998 displays negligible binding to Fc receptors.

Alternative names

LILRB1, ILT2, LIR-1, MIR-7

Detailed product information

Technical specifications

CloneREA998
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD85j (ILT2)
Alternative names of antigenLILRB1, ILT2, LIR-1, MIR-7
Molecular mass of antigen [kDa]68
Distribution of antigenB cells, dendritic cells, lymphocytes, monocytes, NK cells, T cells, plasma cells
Entrez Gene ID10859
RRIDAB_2727672, AB_2727627, AB_2727623, AB_2727669, AB_2727624, AB_2727670, AB_2727625, AB_2727671, AB_2727626, AB_2727668

Resources for CD85j (ILT2) Antibody, anti-human, REAfinity™

References for CD85j (ILT2) Antibody, anti-human, REAfinity™

Publications

  1. Borges, L. et al. (1997) A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J. Immunol. 159: 5192-5196
  2. Morel, E. and Bellón, T. (2008) HLA Class I molecules regulate IFN-{gamma} production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j. J. Immunol. 181: 2368 -2381
  3. Merlo, A. et al. (2005) Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes. Clin. Diagn. Lab. Immunol. 12: 705-712

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