Clone:
GHI/75
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2bκ
Applications:
FC, MICS, IF, IHC
Alternative names:
LILRB1, ILT2, LIR-1, MIR-7

Specifications for CD85j (ILT2) Antibody, anti-human

Overview

Clone GHI/75 reacts with CD85j (ILT2), an inhibitory immunoreceptor of the immunoglobulin-like transcript (ILT) family. CD85j is a type I transmembrane protein with four extracellular Ig-like domains and four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail. The inhibitory signal is transmitted by recruiting SH2-containing protein tyrosine phosphatase-1 that dephosphorylates and inactivates downstream tyrosine kinases. Expression of CD85j is found on B cells, monocytes, dendritic cells, and subsets of natural killer (NK) and T cells. CD85j is known to bind classical and non-classical MHC class I molecules, human cytomegalovirus UL18 protein, and some HLA-C alleles, as ligands. Crosslinking of CD85j prevents activation of B cells, T cells, NK cells, macrophages, and downregulation of effector mechanisms, such as NK and T cells cytolytic functions.

Alternative names

LILRB1, ILT2, LIR-1, MIR-7

Detailed product information

Technical specifications

CloneGHI/75
Clonalitymonoclonal
Isotypemouse IgG2bκ
Isotype controlIsotype Control Antibody, mouse IgG2b
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD85j (ILT2)
Alternative names of antigenLILRB1, ILT2, LIR-1, MIR-7
Molecular mass of antigen [kDa]68
Distribution of antigenB cells, dendritic cells, monocytes, NK cells, T cells, lymphocytes, leukemia cells, plasma cells
Entrez Gene ID10859
RRIDAB_2819744, AB_2659382, AB_2659385, AB_2659386, AB_2659387, AB_2819749

Resources for CD85j (ILT2) Antibody, anti-human

References for CD85j (ILT2) Antibody, anti-human

Publications

  1. Borges, L. et al. (1997) A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. J. Immunol. 159: 5192-5196
  2. Morel, E. and Bellón, T. (2008) HLA Class I molecules regulate IFN-{gamma} production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j. J. Immunol. 181: 2368 -2381
  3. Merlo, A. et al. (2005) Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes. Clin. Diagn. Lab. Immunol. 12: 705-712

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