Type of antibody:
Primary antibodies
hamster IgG
Alternative names:
B29, Igbeta, Igb

Specifications for CD79b Antibody, anti-mouse


Clone HM79-12 recognizes the mouse CD79b antigen, a 35-40kD Single-pass type I membrane protein also known as B-cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre-B cells from pro-B cells, surface expression of surface Ig, signal transduction following antigen recognition and endocytosis of recognized antigens. Crosslinking of CD79b in vitro by monoclonal antibodies activates pre-B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79α and CD79β monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice.

Alternative names

B29, Igbeta, Igb

Detailed product information

Technical specifications

Isotypehamster IgG
Type of antibodyPrimary antibodies
Alternative names of antigenB29, Igbeta, Igb
Molecular mass of antigen [kDa]23
Distribution of antigenB cells
Entrez Gene ID15985
RRIDAB_2659221, AB_2659222, AB_2659223, AB_2659224, AB_2659225, AB_2659226, AB_2659227, AB_2659228, AB_2659229, AB_2659220

Resources for CD79b Antibody, anti-mouse

References for CD79b Antibody, anti-mouse


  1. Li, Y. et al. (2008) B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J. Immunol. 181(5): 2961-2972
  2. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
  3. O'Neill, S. K. et al. (2011) Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity 35(5): 746-756

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