Clone:
HM79-12
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC, MICS, IF, IHC
Alternative names:
B29, Igbeta, Igb

Specifications for CD79b Antibody, anti-mouse

Overview

Clone HM79-12 recognizes the mouse CD79b antigen, a 35-40kD Single-pass type I membrane protein also known as B-cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre-B cells from pro-B cells, surface expression of surface Ig, signal transduction following antigen recognition and endocytosis of recognized antigens. Crosslinking of CD79b in vitro by monoclonal antibodies activates pre-B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79α and CD79β monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice.

Alternative names

B29, Igbeta, Igb

Detailed product information

Technical specifications

CloneHM79-12
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD79b
Alternative names of antigenB29, Igbeta, Igb
Molecular mass of antigen [kDa]23
Distribution of antigenB cells
Entrez Gene ID15985
RRIDAB_2659221, AB_2659222, AB_2659223, AB_2659224, AB_2659225, AB_2659226, AB_2659227, AB_2659228, AB_2659229, AB_2659220

Resources for CD79b Antibody, anti-mouse

References for CD79b Antibody, anti-mouse

Publications

  1. Li, Y. et al. (2008) B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J. Immunol. 181(5): 2961-2972
  2. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
  3. O'Neill, S. K. et al. (2011) Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity 35(5): 746-756

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