Clone:
REA410
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, IHC, MICS, IF
Alternative names:
Ceacam1, BGP, BGP-1, MHV-R, MHVR1, Bgpd, CEACAM1

Specifications for CD66a Antibody, anti-mouse, REAfinity™

Overview

Clone REA410 recognizes the mouse CD66a antigen, a Single-pass type I membrane protein which is also known as Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). CD66a is an adhesion molecule that is involved in many immune responses associated with infection, inflammation and cancer. In the mouse, CD66a is expressed on the plasma membranes of a variety of cells and tissues like endothelial cells, macrophages, dendritic cells, thymic epithelial cells, B lymphocytes and activated T lymphocytes. CD66a is also the principal receptor for mouse hepatitis virus (MHV). Wild mice have two alleles of the mCeacam1 gene, called mCeacam1a and mCeacam1b. Inbred mouse strains that are homozygous for the isoform Ceacam1a, including BALB/c, C57BL/6 (B6), C3H, and A/J mice, are highly susceptible to infection with strains of MHV. In contrast, the SJL line of inbred mice, which is resistant to death from MHV infection, is homozygous for the Ceacam1b isoform, which is not recognized by clone REA410.
Additional information: Clone REA410 displays negligible binding to Fc receptors.

Alternative names

Ceacam1, BGP, BGP-1, MHV-R, MHVR1, Bgpd, CEACAM1

Detailed product information

Technical specifications

CloneREA410
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD66a
Alternative names of antigenCeacam1, BGP, BGP-1, MHV-R, MHVR1, Bgpd, CEACAM1
Molecular mass of antigen [kDa]54
Distribution of antigenendothelial cells, epithelial cells, dendritic cells, macrophages, lymphocytes
Entrez Gene ID26365
RRIDAB_2658958, AB_2658959, AB_2658962, AB_2658963, AB_2658964, AB_2658965, AB_2658966, AB_2658967, AB_2658968, AB_2658969, AB_2877002

References for CD66a Antibody, anti-mouse, REAfinity™

Publications

  1. Chen, L. et al. (2012) The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity 37(5): 930-946
  2. Mima, J. et al. (2013) Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One 8(4): e61653
  3. Dveksler, G. S. et al. (1993) Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. J. Virol. 67(1): 1-8

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