Clone:
REA170
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Integrin-associated protein, IAP, Itgp, CD47

Specifications for CD47 Antibody, anti-mouse, REAfinity™

Overview

Clone REA170 recognizes CD47, which is also known as integrin-associated protein. CD47 is a 50 KDa heavily glycosylated protein with an extracellular IgV domain, five transmembrane domains and a cytoplasmic tail, which exists in 4 different isoforms. The expression of CD47 varies in different tissue types depending upon the cytoplasmic tail isoform associated, for e.g the 16 amino acid form 2, is expressed in all cells of hematopoietic origin, endothelial and epithelial cells whereas 36 amino acids form 4 is expressed mainly in neurons, intestine, and testis. CD47 can interact with integrins, Thrombospondin-1 (TSP-1), cell surface gylcoproteins SIRPα and SIRPβ. Owing to these interactions, CD47 plays an important role in lymphocyte homeostasis, maturation and activation of dendritic cells, cellular transmigration and phagocytosis of cells.
Additional Information: Clone REA170 displays negligible binding to Fc receptors.

Alternative names

Integrin-associated protein, IAP, Itgp, CD47

Detailed product information

Technical specifications

CloneREA170
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD47
Alternative names of antigenIntegrin-associated protein, IAP, Itgp, CD47
Distribution of antigenB cells, endothelial cells, epithelial cells, T cells
RRIDAB_2659753, AB_2659754, AB_2659755, AB_2659756, AB_2659757, AB_2659758, AB_2659743, AB_2659744, AB_2659745, AB_2659746, AB_2659747, AB_2659748, AB_2659751, AB_2659752

Resources for CD47 Antibody, anti-mouse, REAfinity™

References for CD47 Antibody, anti-mouse, REAfinity™

Publications

  1. Demeure, C. E. et al. (2000) CD47 engagement inhibits cytokine production and maturation of human dendritic cells. J. Immunol. 164: 2193-2199

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