Clone:
REA975
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
CD3e, CD3epsilon, T3E

Specifications for CD3ε (intracellular) Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA975 recognizes an intracellular part of the CD3ε chain (activation epitope). CD3ε is a single-pass type I membrane protein, which is a part of the CD3 complex and a subunit of the TCR complex. The CD3 complex mediates signal transduction in several intracellular pathways and has a role in T cell activation and antigen recognition by binding the peptide/MHC antigen complex. CD3ε is expressed on all mature T lymphocytes, NKT cells, and during the development of thymocytes.
Additional information: Clone REA975 displays negligible binding to Fc receptors.

Alternative names

CD3e, CD3epsilon, T3E

Detailed product information

Technical specifications

CloneREA975
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenCD3ε (intracellular)
Alternative names of antigenCD3e, CD3epsilon, T3E
Molecular mass of antigen [kDa]21
Distribution of antigenT cells, NKT cells, thymocytes
Entrez Gene ID916
RRIDAB_2727389, AB_2727452, AB_2727390, AB_2727453, AB_2727391, AB_2727888, AB_2727851, AB_2727889, AB_2727852, AB_2727451

Resources for CD3ε (intracellular) Antibody, anti-human/mouse, REAfinity™

References for CD3ε (intracellular) Antibody, anti-human/mouse, REAfinity™

Publications

  1. Gold, D. P. et al. (1987) Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proc. Natl. Acad. Sci. U.S.A. 84(21): 7649-7653
  2. Clevers, H. et al. (1988) Characterization and expression of the murine CD3-epsilon gene. Proc. Natl. Acad. Sci. U.S.A. 85(22): 8623-8627
  3. Soudais, C. et al. (1993) Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency. Nat. Genet. 3(1): 77-81

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