Specifications for CD357 (GITR) Antibody, anti-mouse, REAfinity™
Overview
Clone REA980 recognizes the mouse CD357 antigen, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18. CD357 is a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4
+CD25
+ regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 (GTITR) with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4
+CD25
+ Tregs.
Additional information: Clone REA980 displays negligible binding to Fc receptors.
Alternative names
GITR, TNFRSF18, AITRDetailed product information
Technical specifications
| Clone | REA980 |
|---|
| Clonality | monoclonal |
|---|
| Isotype | recombinant human IgG1 |
|---|
| Isotype control | REA Control Antibody, human IgG1 |
|---|
| Host | human cell line |
|---|
| Type of antibody | Primary antibodies, Recombinant antibodies |
|---|
| Species | mouse |
|---|
| Antigen | CD357 (GITR) |
|---|
| Alternative names of antigen | GITR, TNFRSF18, AITR |
|---|
| Molecular mass of antigen [kDa] | 23 |
|---|
| Distribution of antigen | T cells, regulatory T cells |
|---|
| Entrez Gene ID | 21936 |
|---|
| RRID | AB_2727489, AB_2727530, AB_2727490, AB_2727531, AB_2727491, AB_2727533, AB_2727493, AB_2727532, AB_2727492, AB_2727528, AB_2727488, AB_2922135, AB_2922139, AB_2727529 |
|---|
