Clone:
REA1097
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
SLAM family receptor, SLAMF6, SLAM F6, LY108, Lymphocyte antigen 108, SLAM family member 6

Specifications for CD352 (NTB-A) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1097 recognizes the mouse CD352 antigen, a single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or NK-, T-, and B-cell antigen (NTB-A) belonging to the CD2 subfamily of the immunoglobulin superfamily. It is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. CD352 plays a role in NK cell cytotoxicity and T cell cytokine responses. It controls neutrophil functions and serves as a regulator of both innate and adaptive immune responses.
Additional information: Clone REA1097 displays negligible binding to Fc receptors.

Alternative names

SLAM family receptor, SLAMF6, SLAM F6, LY108, Lymphocyte antigen 108, SLAM family member 6

Detailed product information

Technical specifications

CloneREA1097
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD352 (NTB-A)
Alternative names of antigenSLAM family receptor, SLAMF6, SLAM F6, LY108, Lymphocyte antigen 108, SLAM family member 6
Molecular mass of antigen [kDa]36
Distribution of antigenB cells, NK cells, T cells
Entrez Gene ID30925
RRIDAB_2733606, AB_2733744, AB_2733745, AB_2733323, AB_2732948, AB_2732949, AB_2733192, AB_2733996, AB_2733997, AB_2733488, AB_2733489, AB_2733605

Resources for CD352 (NTB-A) Antibody, anti-mouse, REAfinity™

References for CD352 (NTB-A) Antibody, anti-mouse, REAfinity™

Publications

  1. Peck, S. R. et al. (2000) Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics 52(1-2): 63-72
  2. Howie, D. et al. (2005) Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J. Immunol. 174(10): 5931-5935
  3. Griewank, K. et al. (2007) Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27(5): 751-762

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