Clone:
REA214
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
AIRM1, CDw328, D-siglec, QA79, Siglec-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1

Specifications for CD328 (Siglec-7) Antibody, anti-human, REAfinity™

Overview

Clone REA214 recognizes CD328, which is a member of sialic acid-binding immunoglobulin-like lectins (siglecs) family of trans-membrane proteins. Upon recognizing their natural ligands, the sialylated carbohydrates, siglecs generally transmit an inhibitory signal. CD328 is a 75 kDa type I trans-membrane protein and further belongs to the human CD33-related siglec receptors with sialic acid binding N-terminal Ig domain, two C2-set Ig domains, and a cytoplasmic region containing one immune-receptor tyrosine based inhibitory motif (ITIM) and one ITIM-like motif. Expression of CD328 is found on natural killer (NK) cells, monocytes, and on a small subset of CD8
+
/CD3
+
T cells and it preferentially binds (2,8)-linked disialic acids and branched 2,6-sialyl residues.
Additional information: Clone REA214 displays negligible binding to Fc receptors.

Alternative names

AIRM1, CDw328, D-siglec, QA79, Siglec-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1

Detailed product information

Technical specifications

CloneREA214
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD328 (Siglec-7)
Alternative names of antigenAIRM1, CDw328, D-siglec, QA79, Siglec-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1
Distribution of antigenmonocytes, NK cells
RRIDAB_2657531, AB_2657532, AB_2657533, AB_2657534, AB_2657535, AB_2657536, AB_2657537, AB_2657538, AB_2657539, AB_2657540, AB_2657541, AB_2657542, AB_2657543, AB_2657544, AB_2657545, AB_2657530

Resources for CD328 (Siglec-7) Antibody, anti-human, REAfinity™

References for CD328 (Siglec-7) Antibody, anti-human, REAfinity™

Publications

  1. Attrill, H. et al. (2006) Siglec-7 undergoes a major conformational change when complexed with the (2,8)-disialylganglioside GT1. J. Biol. Chem. 281: 32774-32783
  2. Angata, T. et al. (2000) Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily. Glycobiology 10: 431-438
  3. Madge, PD. et al. (2016) Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. Sci. Rep. 6: 36012

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