Clone REAL829 is an antibody fragment derived from the full CD31 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL829 recognizes the human CD31 antigen. also known as PECAM-1 or EndoCAM. CD31 is a member of the immunoglobulin superfamily and is involved in leukocyte transmigration, angiogenesis, and integrin activation. CD31 is a 120–140 kDa single-chain transmembrane glycoprotein expressed on endothelial cells, monocytes, platelets, granulocytes and several lymphocyte subsets. During maturation of CD4
+ T cells, the expression of CD31 changes: CD4
+ recent thymic emigrants (RTEs) express CD31 in contrast to central naive T cells. CD31 is highly expressed on endothelial cells, especially at their juncture and is used as a marker for endothelial differentiation in human neoplasms.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
