Clone:
REA1070
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6

Specifications for CD300e (IREM-2) Antibody, anti-human, REAfinity™

Overview

Clone REA1070 recognizes the human CD300e, also known as IREM-2, LMIR6, or CMRF35-A5. This 34 kDa activating receptor of the immunglobulin superfamily is expressed on mature myeloid dendritic cells and monocytes and is down-regulated on immature dendritic cells (DCs). CD300e interacts with DAP-12, which mediates acivating signals. It is reported that the alloreactive response of naive T cells is enhanced by IREM-2 activation of mDCs.
Additional information: Clone REA1070 displays negligible binding to Fc receptors.

Alternative names

CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6

Detailed product information

Technical specifications

CloneREA1070
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD300e (IREM-2)
Alternative names of antigenCD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6
Molecular mass of antigen [kDa]21
Distribution of antigendendritic cells, monocytes, myeloid dendritic cells
Entrez Gene ID342510
RRIDAB_2733597, AB_2733726, AB_2733727, AB_2733305, AB_2733306, AB_2733926, AB_2733927, AB_2734085, AB_2734086, AB_2732933, AB_2732934, AB_2733179, AB_2733180, AB_2733083, AB_2733084, AB_2733017, AB_2733018, AB_2733982, AB_2733983, AB_2733476, AB_2733477, AB_2801920, AB_2733596

Resources for CD300e (IREM-2) Antibody, anti-human, REAfinity™

References for CD300e (IREM-2) Antibody, anti-human, REAfinity™

Publications

  1. Aguilar, H. et al. (2004) Molecular characterization of a novel immune receptor restricted to the monocytic lineage. J. Immunol. 173: 6703-6711
  2. Brckalo, T. et al. (2010) Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. Eur. J. Immunol. 40(3): 722-732

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