Clone:
HTA125
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2aκ
Applications:
FC
Alternative names:
TLR4, ARMD10, TLR-4, TOLL

Specifications for CD284 Antibody, anti-human

Overview

Clone HTA125 reacts with CD284, a type I transmembrane signaling receptor also known as Toll-like receptor 4 (TLR4). Toll-like receptors are a family of pattern recognition receptors detecting the presence and characteristics of an infection and induce appropriately tailored innate and adaptive immune responses. TLR4 associates with its co-receptor MD-2. Together with the lipopolysaccharide (LPS)-binding protein (LBP) and CD14, this complex is responsible for signaling upon LPS recognition. TLR4 is expressed on monocytes and myeloid dendritic cells. Low levels are expressed on B cells and granulocytes in human peripheral blood. HTA125 is able to block LPS-induced signaling and recognizes predominantly human TLR4 associated with MD-2.

Alternative names

TLR4, ARMD10, TLR-4, TOLL

Detailed product information

Technical specifications

CloneHTA125
Clonalitymonoclonal
Isotypemouse IgG2aκ
Isotype controlIsotype Control Antibody, mouse IgG2a
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, other
Cross-reactivityrabbit, guinea pig
AntigenCD284
Alternative names of antigenTLR4, ARMD10, TLR-4, TOLL
Molecular mass of antigen [kDa]93
Distribution of antigendendritic cells, endothelial cells, granulocytes, macrophages, monocytes, T cells, stem cells, leukocytes, placenta, spleen
Entrez Gene ID7099
RRIDAB_2857625, AB_2660688, AB_10829185, AB_2660689, AB_10829615, AB_2660690, AB_2857652

Resources for CD284 Antibody, anti-human

References for CD284 Antibody, anti-human

Publications

  1. Jin, M. S. and Lee, J-O. (2008) Structures of the toll-like receptor family and its ligand complexes. Immunity 29: 182-191
  2. Shimazu, R. et al. (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189: 1777-1782
  3. Burgener, I. et al. (2008) Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet. Immunol. Immunopathol. 124: 184-191
  4. Kawahara, T. et al. (2001)
    Type I
    Helicobacter pylori
    lipopolysaccharide stimulates Toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells.
    Infect. Immun. 69: 4382-4389
  5. Wang, J. et al. (2001)
    Involvement of CD14 and Toll-Like receptors in activation of human monocytes by
    Aspergillus fumigatus
    hyphae.
    Infect. Immun. 69: 2402-2406
  6. Wang, R. et al. (2003) Characterization of monoclonal antibody HTA125 with specificity for human TLR4. Hybrid. Hybridomics 22: 357-365

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CD284 Antibody, anti-human

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