Clone:
TLR 3.7
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
ICFC, MICS, IF, IHC
Alternative names:
TLR3, IIAE2

Specifications for CD283 (TLR3) Antibody, anti-human

Overview

The monoclonal antibody TLR 3.7 reacts with CD283, also known as toll-like receptor 3 (TLR3). Toll-like receptors are a family of pattern recognition receptors that have evolved to detect components of foreign pathogens referred to as pathogenassociated molecular patterns. TLR3 is a single-pass type I membrane protein expressed exclusively in intracellular vesicles, such as the endoplasmic reticulum (ER), endosomes, lysosomes, and endolysosomes, where it recognizes microbial dsRNA. Multiple cell types are known to express TLR3 including dendritic cells, keratinocytes, and neurons. TLR3 activates via the TRIF-dependent pathway antiviral immune responses through the production of type I interferon and inflammatory cytokines, suggesting that TLR3 has an essential role in the prevention of viral infection.

Alternative names

TLR3, IIAE2

Detailed product information

Technical specifications

CloneTLR 3.7
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenCD283 (TLR3)
Alternative names of antigenTLR3, IIAE2
Molecular mass of antigen [kDa]101
Distribution of antigendendritic cells, epithelial cells, fibroblasts, pancreas, placenta
Entrez Gene ID7098
RRIDAB_2660000, AB_2660001, AB_2660002, AB_2660003, AB_2660004, AB_2660005, AB_2659999

Resources for CD283 (TLR3) Antibody, anti-human

References for CD283 (TLR3) Antibody, anti-human

Publications

  1. Visintin, A. et al. (2001) Regulation of Toll-like receptors in human monocytes and dendritic cells. J. Immunol. 166: 249
  2. Sonali, K. and Reinhardt, T. A. (2005) Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency. J. Immunol. 175: 5314-5323
  3. Alexopoulou, L. et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413(6587): 732-738
  4. Oshiumi, H. et al. (2003) TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction. Nat. Immunol. 4: 161-167
  5. Rock, F. L. et al. (1998) A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U.S.A. 95: 588-593
  6. Matsumoto, M. et al. (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 293: 1364-1369
  7. Jorgenson, R. L. et al. (2005) Human endometrial epithelial cells cyclically express toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. Hum. Immunol. 66(5): 469-482
  8. de Bouteiller, O. et al. (2005) Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J. Biol. Chem. 280: 38133-38145
  9. Lafon, M. et al. (2006) The innate immune facet of brain: human neurons express TLR-3 and sense vial dsRNA. J. Mol. Neurosci. 29: 185-194

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