Clone:
REA524
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
2B4, NKR2B4, 2B4 B6 Alloantigen, SLAMF4

Specifications for CD244.1 Antibody, anti-mouse, REAfinity™

Overview

Clone REA524 recognizes an alloantigen of the mouse CD244 antigen, a single-pass type I membrane protein, which is also known as 2B4. CD244 is a receptor belonging to the CD2 subfamily of the Ig superfamily and is involved in non-MHC dependent cytotoxicity. Expression of CD244 is found on all NK cells, γδ T cells, basophils, and monocytes as well as a subset of memory-phenotype CD8
+
αβ T cells. The ligand of CD244 is CD48, which is expressed on all hematopoietic cells. CD244 is primarily involved in inhibiting NK cell functions. In inbred mice, at least two splice variants exist that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner, while the short form functions in an activating manner. Clone REA524 reacts with CD244.1, the CD244 alloantigen which is expressed on most inbred mouse strains except C57BL/6 and C58, which express the CD244.2 allotype.
Additional information: Clone REA524 displays negligible binding to Fc receptors.

Alternative names

2B4, NKR2B4, 2B4 B6 Alloantigen, SLAMF4

Detailed product information

Technical specifications

CloneREA524
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD244.1
Alternative names of antigen2B4, NKR2B4, 2B4 B6 Alloantigen, SLAMF4
Molecular mass of antigen [kDa]43
Distribution of antigenmonocytes, NK cells, T cells, basophils
Entrez Gene ID18106
RRIDAB_2656617, AB_2656618, AB_2656619, AB_2656620, AB_2656621, AB_2656622, AB_2656623, AB_2656624, AB_2656625, AB_2656616

Resources for CD244.1 Antibody, anti-mouse, REAfinity™

References for CD244.1 Antibody, anti-mouse, REAfinity™

Publications

  1. Mathew, P. A. et al. (1993) Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J. Immunol. 151(10): 5328-5337
  2. Kumaresan, P. R. et al. (2000) Polymorphism in the 2B4 gene of inbred mouse strains. Immunogenetics 51(8-9): 758-761
  3. McNerney, M. E. et al. (2005)
    2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8
    +
    T cells.
    Mol. Immunol. 42(4): 489 -494

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CD244.1 Antibody, anti-mouse, REAfinity™

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