Clone REA460 recognizes the human CD204 antigen, a single-pass type II membrane protein which is also known as macrophage scavenger receptor type I (MSR1) or scavenger receptor class A (SR-A). CD204 is one of the major scavenger receptors expressed on human macrophages and dendritic cells. It plays roles in lipid metabolism, atherogenesis, and a number of metabolic processes. Recent evidence also points to important roles for CD204 in inflammation, innate immunity, host defense, sepsis, and ischemic injury. CD204 inhibits macrophage activation by scavenging ligands of toll-like receptor 4 and suppresses inflammatory cytokine production. Immunohistochemical studies in gliomas, pancreatic cancer, kidney cancer, esophageal cancer, and lung cancer have shown that CD204 expression in tumor tissues is closely restricted to tumor-associated macrophages and that high expression of CD204 is associated with a high malignant potential of tumor cells.

Additional information: Clone REA460 displays negligible binding to Fc receptors.