Clone:
REA583
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
TIE2, TIE-2, p140 TEK

Specifications for CD202b pY1102 Antibody, anti-human, REAfinity™

Overview

Clone REA583 recognizes the Y1102-phosphorylated form of CD202b, which is 145 kDa type I transmembrane tyrosine kinase receptor. CD202b is composed of an amino-terminal ligand binding domain with immunoglobulin domains, epithelial growth factor repeats, and fibronectin-like 3 repeats, a single transmembrane domain, and an intracellular tyrosine kinase domain. Expression of CD202b is found on endothelial cells and a subpopulation of monocytes. Angiopoietins are the natural ligands of CD202b. Activation of CD202b dependent signaling pathways are involved in survival and apoptosis of endothelial cells, in controlling vascular permeability, and regulation of the capillary sprouting that occurs during normal angiogenesis.
Additional information: Clone REA583 displays negligible binding to Fc receptors.

Alternative names

TIE2, TIE-2, p140 TEK

Detailed product information

Technical specifications

CloneREA583
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD202b pY1102
Alternative names of antigenTIE2, TIE-2, p140 TEK
Molecular mass of antigen [kDa]124
Distribution of antigenendothelial cells, hematopoietic stem and progenitor cells
Entrez Gene ID7010
RRIDAB_2656159, AB_2656158

Resources for CD202b pY1102 Antibody, anti-human, REAfinity™

References for CD202b pY1102 Antibody, anti-human, REAfinity™

Publications

  1. Murdoch, C. et al. (2007) Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J. Immunol. 178: 7405-7411
  2. Sato, T. N. et al. (1993) Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. U.S.A. 90: 9355-9358
  3. Schnurch, H. et al. (1993) Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage. Development 119: 957-968

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