Clone:
REA532
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Cspmo2, MRCOX2, Mox2

Specifications for CD200 Antibody, anti-rat, REAfinity™

Overview

Clone REA532 recognizes the rat CD200 antigen, which is a transmembrane glycoprotein containing two extracellular immunoglobulin domains and lacks intracellular signaling motifs or docking sites for adapter signaling molecules. CD200, also known as MRC OX-2 antigen, is expressed on a variety of tissues, including the nervous system, activated T cells, B cells, dendritic cells in lymphatic follicles, cells of glomeruli and ovarian degenerating follicles, and vascular endothelium. It is also distributed at the epithelium-derived tissues such as the thymus, retinas, and hair follicles. CD200 interacts with CD200R, an immunoglobulin superfamily inhibitory receptor expressed primarily on myeloid/monocyte lineage cells, and has a suppressive effect on T cell–mediated immune response.
Additional information: Clone REA532 displays negligible binding to Fc receptors.

Alternative names

Cspmo2, MRCOX2, Mox2

Detailed product information

Technical specifications

CloneREA532
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD200
Alternative names of antigenCspmo2, MRCOX2, Mox2
Molecular mass of antigen [kDa]28
Distribution of antigenT cells, B cells, dendritic cells, endothelial cells, ovary
Entrez Gene ID24560
RRIDAB_2656094, AB_2656095, AB_2656096, AB_2656097, AB_2656098, AB_2656099, AB_2656100, AB_2656101, AB_2656102, AB_2656103, AB_2656104, AB_2656105, AB_2656106, AB_2656093

Resources for CD200 Antibody, anti-rat, REAfinity™

References for CD200 Antibody, anti-rat, REAfinity™

Publications

  1. Clark, M. J. et al. (1985) MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a structure like a single immunoglobulin light chain. EMBO J. 4(1): 113-118
  2. Ya-Fen, J. S. et al. (2010) Distribution and expression of CD200 in the rat respiratory system under normal and endotoxin-induced pathological conditions. J. Anat. 216(3): 407-416
  3. Barclay, A. N. et al. (1986) Neuronal/lymphoid membrane glycoprotein MRC OX-2 is a member of the immunoglobulin superfamily with a light-chain-like structure. Biochem. Soc. Symp. 51: 149-157

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