Clone:
REA1067
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
MOX1, Mox2, MRC, OX2, MOX1/2

Specifications for CD200 Antibody, anti-human, REAfinity™

Overview

Clone REA1067 recognizes the human CD200 antigen, also known as MRC, MOX1/2, or OX-2, a type 1 membrane glycoprotein, which contains two immunoglobulin domains. Studies of the related gene in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. CD200 may serve as a cancer stem cell marker as co-expression with other reported stem cell markers was found on prostate, breast, brain, and colon cancers. In addition, CD200 expression was shown to be a prognostic factor in AML and multiple myeloma.
Additional information: Clone REA1067 displays negligible binding to Fc receptors.

Alternative names

MOX1, Mox2, MRC, OX2, MOX1/2

Detailed product information

Technical specifications

CloneREA1067
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD200
Alternative names of antigenMOX1, Mox2, MRC, OX2, MOX1/2
Molecular mass of antigen [kDa]28
Distribution of antigenB cells, dendritic cells, endothelial cells, neurons, T cells, tumor cells, mesenchymal stem cells, thymocytes
Entrez Gene ID4345
RRIDAB_2733627, AB_2733784, AB_2733785, AB_2733355, AB_2733356, AB_2732968, AB_2732969, AB_2733216, AB_2733217, AB_2734010, AB_2734011, AB_2733508, AB_2733509, AB_2733626

Resources for CD200 Antibody, anti-human, REAfinity™

References for CD200 Antibody, anti-human, REAfinity™

Publications

  1. Minas, K. et al. (2006) Is the CD200/CD200 receptor interaction more than just a myeloid cell inhibitory signal? Crit. Rev. Immunol. 26: 213-230
  2. Kawasaki, B. T. et al. (2007) Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells. Biochem. Biophys. Res. Commun. 364: 778-782
  3. Moreaux, J. et al. (2007) CD200 as a prognostic factor in acute myeloid leukemia. Blood 108: 4194-4197
  4. Tonks, A. et al. (20007) CD200 as a prognostic factor in acute myeloid leukemia. Leukemia 21: 566-568

Related products for
CD200 Antibody, anti-human, REAfinity™

3 products available