Clone:
CXCR3-173
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC, MICS, IHC, IF
Alternative names:
CXCR3, CMKAR3

Extended validation for CD183 (CXCR3) Antibody, anti-mouse

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with CXCR-173
220803++
REA724++
S18001A++
Cells were incubated with an excess of purified unconjugated CD183 (CXCR3) (CXCR3-173) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD183 (CXCR3) Antibody, anti-mouse

Overview

The monoclonal antibody CXCR3-173 reacts with mouse CD183, also known as CXCR3, which is a 40 kDa seven-transmembrane protein belonging to the G protein-coupled receptor family. CXCR3 binds the ligands CXCL9, CXCL10 and CXCL11 and mediates Ca
2+
mobilization and chemotaxis. It is expressed on activated T cells, circulating blood T cells, B cells and NK cells.

Alternative names

CXCR3, CMKAR3

Detailed product information

Technical specifications

CloneCXCR3-173
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD183 (CXCR3)
Alternative names of antigenCXCR3, CMKAR3
Molecular mass of antigen [kDa]41
Distribution of antigenB cells, dendritic cells, NK cells, T cells, eosinophils, plasma cells, heart, kidney, liver, placenta, skeletal muscle
Entrez Gene ID12766
RRIDAB_2655753, AB_2655752

References for CD183 (CXCR3) Antibody, anti-mouse

Publications

  1. Loetscher, M. et al. (1996) Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J. Exp. Med. 184(3): 963-969
  2. Qin, S. et al. (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. Clin. Invest. 101 (4): 746-754
  3. Wells, T. N. et al. (1998) Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol. Sci. 19(9): 376-380