Clone:
REAL756
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CXCR3, CKR-L2, CMKAR3, IP10-R, Mig-R, MigR

Specifications for CD183 (CXCR3) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL756 is an antibody fragment derived from the full CD183 (CXCR3) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL756 recognizes CD183, a 38 kDa G protein–coupled chemokine receptor. CD183 harbors seven-transmembrane α-helices, an extracellular N-terminal domain containing three loops involved in the chemokine ligand binding, an intracellular C-terminal domain involved in signal transduction. CD183 binds CXCL9, CXCL10, and CXCL11 as ligands. CD183-ligand interactions play role in diverse cellular functions such as chemotactic migration, cell proliferation, and death. Expression of CD183 is found on T cells, human airway epithelial cells, NK cells, plasmacytoid dendritic cells, mast cells, alveolar macrophages, and eosinophils. CD183 functions as a prognostic marker for renal and endometrial cancer, melanoma and head and neck cancer.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CXCR3, CKR-L2, CMKAR3, IP10-R, Mig-R, MigR

Detailed product information

Technical specifications

CloneREAL756
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD183 (CXCR3)
Alternative names of antigenCXCR3, CKR-L2, CMKAR3, IP10-R, Mig-R, MigR
Distribution of antigenT cells, epithelial cells, NK cells, dendritic cells, mast cells, macrophages, granulocytes, tumor cells, eosinophils, colon
RRIDAB_2857794, AB_2857796

References for CD183 (CXCR3) Antibody, anti-human, REAdye_lease™

Publications

  1. Hu, J. K. et al. (2011) Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation. Proc. Natl. Acad. Sci. U.S.A. 108: E118-E127
  2. Colvin, R. A. et al. (2004) Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function. J. Biol. Chem. 279: 30219-30227