Clone:
M18/2
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, IF, IHC, FA
Alternative names:
Integrin beta-2 (ITGB2), 2E6, LAD, Lfa1, MF17, LCAMB, TNFR2-RP, TNFRrp, Tnfbr

Specifications for CD18 Antibody, anti-mouse

Overview

Clone M18/2 recognizes the CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.

Alternative names

Integrin beta-2 (ITGB2), 2E6, LAD, Lfa1, MF17, LCAMB, TNFR2-RP, TNFRrp, Tnfbr

Detailed product information

Technical specifications

CloneM18/2
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD18
Alternative names of antigenIntegrin beta-2 (ITGB2), 2E6, LAD, Lfa1, MF17, LCAMB, TNFR2-RP, TNFRrp, Tnfbr
Molecular mass of antigen [kDa]86,7
Distribution of antigenT cells, NK cells
Entrez Gene ID16414
RRIDAB_2655665, AB_2655678, AB_2655679, AB_2655680, AB_2655681, AB_2655682, AB_2655683, AB_2655684, AB_2655685, AB_2655686, AB_2655687

Resources for CD18 Antibody, anti-mouse

References for CD18 Antibody, anti-mouse

Publications

  1. Wilson, R. W. et al. (1993) Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151: 1571-1578
  2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269
  3. Jakus, Z. et al. (2007) Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends Cell Biol. 17(10): 493-501

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