Clone:
TS1/18
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7

Extended validation for CD18 Antibody, anti-human

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with TS1/18
6.7-
REA1112++
1B4/CD18+
CBR LFA-1/2-
MEM-148+
Cells were incubated with an excess of purified unconjugated CD18 (TS1/18) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD18 Antibody, anti-human

Overview

Clone TS1/18 reacts with CD18, a type I transmembrane protein with an approximate molecular weight of 90–95 kDa. It non-covalently associates with α subunits CD11a (αL), CD11b (αM), CD11c (αX), and CD11d (αD) to form functional integrins which are expressed on leucocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.

Alternative names

ITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7

Detailed product information

Technical specifications

CloneTS1/18
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, other
Cross-reactivityporcine
AntigenCD18
Alternative names of antigenITGB2, CD18, LAD, LCAMB, LFA-1, Mac-1 α, MF17, MFI7
Distribution of antigenleukocytes
RRIDAB_2784020, AB_2889485, AB_2889484, AB_2904789, AB_2904788, AB_2655672, AB_2655673, AB_2655674, AB_2655675, AB_2784021

Resources for CD18 Antibody, anti-human

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD18 Antibody, anti-human

Publications

  1. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269

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