Clone:
NOK-1
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6

Specifications for CD178 Antibody, anti-human

Overview

Clone NOK-1 reacts with CD178, a type II transmembrane glycoprotein, also known as Fas ligand or CD95L. It is expressed on activated lymphocytes, e.g., T cells, NK cells, monocytes, or granulocytes, as well as at immune-privileged sites, e.g., cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane-bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules.

Alternative names

FASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6

Detailed product information

Technical specifications

CloneNOK-1
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD178
Alternative names of antigenFASLG, ALPS1B, APT1LG1, APTL, CD95L, FasL, TNFSF6
Molecular mass of antigen [kDa]31
Distribution of antigendendritic cells, endothelial cells, epithelial cells, granulocytes, monocytes, NK cells, T cells, neutrophils, thymocytes
Entrez Gene ID356
RRIDAB_2751489, AB_2857422, AB_2857420, AB_2857826, AB_2857819, AB_10828692, AB_2751526

Resources for CD178 Antibody, anti-human

References for CD178 Antibody, anti-human

Publications

  1. Kayagaki, N. et al. (1995) Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182: 1777-1783
  2. Suda, T. et al. (1993) Molecular cloning and expression of human Fas ligand. Cell 75: 1169-1178
  3. Janssen, O. et al. (2003) CD95 ligand – death factor and costimulatory molecule? Cell Death Differ. 10: 1215-1225

Related products for
CD178 Antibody, anti-human

3 products available