Clone:
REA479
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
SIRPG, SIRP-g, SIRPB2, SIRPgamma

Specifications for CD172g (SIRPγ) Antibody, anti-human, REAfinity™

Overview

Clone REA479 recognizes the human CD172g antigen, a single-pass type I membrane protein also known as signal-regulatory protein γ (SIRPγ) or signal-regulatory protein β 2 (SIRPβ2). Signal regulatory proteins (SIRPs) are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. CD172g is the only member of the SIRP family that is expressed on T cells, some B cells, CD56
bright
natural killer (NK) cells, and all activated NK cells. CD172g does bind CD47, albeit with less affinity than CD172a (SIRPα). This interaction mediates cell-cell adhesion, rather than inhibitory signals. The adhesion mediated by contact of CD172g on T cells with CD47 on antigen-presenting cells (APCs) promotes antigen-specific T cell proliferation and costimulates T cell activation.
Additional information: Clone REA479 displays negligible binding to Fc receptors.

Alternative names

SIRPG, SIRP-g, SIRPB2, SIRPgamma

Detailed product information

Technical specifications

CloneREA479
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD172g (SIRPγ)
Alternative names of antigenSIRPG, SIRP-g, SIRPB2, SIRPgamma
Molecular mass of antigen [kDa]40
Distribution of antigenB cells, NK cells, T cells
Entrez Gene ID55423
RRIDAB_2655632, AB_2655633, AB_2655634, AB_2655635, AB_2655636, AB_2655637, AB_2655638, AB_2655631

Resources for CD172g (SIRPγ) Antibody, anti-human, REAfinity™

References for CD172g (SIRPγ) Antibody, anti-human, REAfinity™

Publications

  1. Piccio, L. et al. (2005) Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. Blood 105(6): 2421-2427
  2. Stefanidakis, M. et al. (2008)
    Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions
    in vitro
    .
    Blood 112(4): 1280-1289
  3. Ichigotani, Y. et al. (2000) Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family. J Hum Genet 45(6): 378-382

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