Clone:
REA936
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF9, 4-1BB, CDw137, ILA, Ly63

Specifications for CD137 Antibody, anti-mouse, REAfinity™

Overview

Clone REA936 recognizes the mouse CD137 antigen, a single-pass type I membrane protein also known as 4-1BB or TNFRSF9, which is a member of the TNFR superfamily. CD137 is expressed on the cell surface of T cells upon activation. The interaction of CD137 with its ligand, 4-1BBL, on antigen-presenting cells delivers a bidirectional co-stimulatory signal. CD137 engagement is shown to be required for CD8
+
T cell survival and memory formation. CD137 is reported to have a strong antagonistic effect in
in vitro
functional assays.
Additional information: Clone REA936 displays negligible binding to Fc receptors.

Alternative names

TNFRSF9, 4-1BB, CDw137, ILA, Ly63

Detailed product information

Technical specifications

CloneREA936
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD137
Alternative names of antigenTNFRSF9, 4-1BB, CDw137, ILA, Ly63
Molecular mass of antigen [kDa]25
Distribution of antigenB cells, epithelial cells, fibroblasts, dendritic cells, T cells, macrophages, monocytes
Entrez Gene ID21942
RRIDAB_2727090, AB_2727049, AB_2727091, AB_2727094, AB_2727050, AB_2727092, AB_2727093, AB_2727089, AB_2727048

Resources for CD137 Antibody, anti-mouse, REAfinity™

References for CD137 Antibody, anti-mouse, REAfinity™

Publications

  1. Pollok, K. E. et al. (1993) Inducible T cell antigen 4-1BB. Analysis of expression and function. J. Immunol. 150(3): 771-781
  2. Tan, J. T. et al. (2000) Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses. Transplantation 70(1): 175-183

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