Specifications for CD134 (OX40) Antibody, anti-rat, REAfinity™
Overview
Clone REA540 recognizes the rat CD134 (OX40) antigen, a 50 kDa glycoprotein which is a member of the TNFR superfamily. It contains a typical signal sequence and a single putative transmembrane sequence of 25 predominantly hydrophobic amino acids giving an extracellular domain of 191 amino acids and a cytoplasmic domain of 36 amino acids. The expression of CD134 is restricted to activated rat CD4
+ T cells and is up-regulated within hours after activation. CD134 and its ligand CD252 (CD134L, OX40L), which is expressed on activated T and B lymphocytes and also a member of the tumor necrosis factor receptor superfamily, were suggested to mediate the interaction between T cells and B cells.
Additional information: Clone REA540 displays negligible binding to Fc receptors.
Alternative names
TNFRSF4, OX-40, Txgp1, MRC OX40Detailed product information
Technical specifications
| Clone | REA540 |
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| Clonality | monoclonal |
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| Isotype | recombinant human IgG1 |
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| Isotype control | REA Control Antibody, human IgG1 |
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| Host | human cell line |
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| Type of antibody | Primary antibodies, Recombinant antibodies |
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| Species | rat |
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| Antigen | CD134 (OX40) |
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| Alternative names of antigen | TNFRSF4, OX-40, Txgp1, MRC OX40 |
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| Molecular mass of antigen [kDa] | 28 |
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| Distribution of antigen | T cells |
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| Entrez Gene ID | 25572 |
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| RRID | AB_2654922, AB_2654923, AB_2654924, AB_2654925, AB_2654926, AB_2654927, AB_2654928, AB_2654921 |
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