Clone:
REA235
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL4RA, IL-4R

Specifications for CD124 (IL-4Rα) Antibody, anti-mouse, REAfinity™

Overview

Clone REA235 recognizes the CD124 antigen, a 140 kDa transmembrane glycoprotein which is also known as interleukin-4 receptor subunit alpha (IL-4Rα). CD124 is expressed on both B and T lymphocytes, and on cells of several other hematopoietic lineages, including mast cell, macrophage, and undifferentiated hematopoietic cell lines. CD124 is a receptor for both IL-4 and IL-13. The functional IL-4 receptor is formed by initial binding of IL-4 to IL-4R. Subsequent recruitment to the complex of the common γ chain, in immune cells, creates a type I receptor and, in non-immune cells, of CD213a1 (IL-13RA1) forms a type II receptor. IL-4R can also interact with the IL-13/CD213a1 complex to form a similar type II receptor. The type I IL-4 receptor complex specifically binds IL-4 whereas the type II IL-4R binds either IL-4 or IL-13. The IL-4/IL-13 responses are involved in regulating the IgE production in B cells and in alternative activation of macrophages. Binding of IL-4 to CD124 on T cells promotes differentiation of Tʜ2 cells. Clone REA235 blocks the binding of IL-4 to cells and also recognizes the soluble truncated form of CD124.
Additional information: Clone REA235 displays negligible binding to Fc receptors.

Alternative names

IL4RA, IL-4R

Detailed product information

Technical specifications

CloneREA235
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD124 (IL-4Rα)
Alternative names of antigenIL4RA, IL-4R
Molecular mass of antigen [kDa]85
Distribution of antigenB cells, T cells, endothelial cells
Entrez Gene ID16190
RRIDAB_2654782, AB_2654783, AB_2654786, AB_2654787, AB_2783925

Resources for CD124 (IL-4Rα) Antibody, anti-mouse, REAfinity™

References for CD124 (IL-4Rα) Antibody, anti-mouse, REAfinity™

Publications

  1. Blum, H. et al. (1996) Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor. J. Immunol. 157(5): 1846-1853
  2. Ohara, J. et al. (1987) Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 325(6104): 537-540
  3. Nelms, K. et al. (1999) The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17: 701-738
  4. Mosley, B. et al. (1989) The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 59(2): 335-348

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