Clone REA520 recognizes the extracellular part of the membrane-bound form of the human CD120b antigen, a 75 kDa single-pass type I membrane protein, which is also known as tumor necrosis factor receptor type II (TNF-RII). CD120b is a receptor with high affinity for the cytokine tumor necrosis factor (TNF-α) and for lymphotoxin-alpha (LT-α). It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.

Additional information: Clone REA520 displays negligible binding to Fc receptors.