Name: CD11b Antibody, anti-mouse, REAlease®
Availability: InStock

Flow cytometry

Conjugate:	PerCP
Recommended dilution:	1:50
Tested:	QC tested
Products used:	130-121-185, 130-124-847

Specifications for CD11b Antibody, anti-mouse,
REAlease
^®

Overview

Clone REAL113 is an antibody fragment derived from the full CD11b antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.

Clone REAL113 recognizes the human and mouse CD11b antigen (Mac-1 α; integrin αM chain), which is part of the CD11b/CD18 heterodimer (Mac-1 α, Mβ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on natural killer (NK) cells and some activated lymphocytes as well as on microglia in the brain. In mice, the CD11b antigen is expressed on monocytes/macrophages and microglia. To a lower extent it is expressed on granulocytes, NK cells, CD5

⁺

B-1 cells, and subsets of dendritic cells. Clone REAL113 recognizes also the non-human primate CD11b antigen.

The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

integrin αM, Mac-1 α, Integrin alpha-M, CR3A, ITGAM, MAC1A, MO1A, SLEB6

Detailed product information

Technical specifications

Clone	REAL113
Clonality	monoclonal
Isotype control	Control Antibody
Host	cell line
Type of antibody	Releasable antibodies, Primary antibodies, Recombinant antibodies
Species	mouse
Cross-reactivity	non-human primate
Antigen	CD11b
Alternative names of antigen	integrin αM, Mac-1 α, Integrin alpha-M, CR3A, ITGAM, MAC1A, MO1A, SLEB6
Distribution of antigen	myeloid cells, NK cells, microglia, lymphocytes, brain
RRID	AB_2783918, AB_2811689

References for CD11b Antibody, anti-mouse,
REAlease
^®

Publications

Pahl, H. L. et al. (1992) Characterization of the myeloid-specific CD11b promoter. Blood 79(4): 865-870
Lebson, L. et al. (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J. Neurosci. 30(29): 9651-9658
Liu, T. et al. (2014)
Gr-1
⁺
CD11b
⁺
cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation.
Sci. Rep. 4: 4833

Applications

Specifications

Specifications for CD11b Antibody, anti-mouse,
REAlease
^®

Overview

⁺

B-1 cells, and subsets of dendritic cells. Clone REAL113 recognizes also the non-human primate CD11b antigen.

Alternative names

integrin αM, Mac-1 α, Integrin alpha-M, CR3A, ITGAM, MAC1A, MO1A, SLEB6

Detailed product information

Technical specifications

Clone	REAL113
Clonality	monoclonal
Isotype control	Control Antibody
Host	cell line
Type of antibody	Releasable antibodies, Primary antibodies, Recombinant antibodies
Species	mouse
Cross-reactivity	non-human primate
Antigen	CD11b
Alternative names of antigen	integrin αM, Mac-1 α, Integrin alpha-M, CR3A, ITGAM, MAC1A, MO1A, SLEB6
Distribution of antigen	myeloid cells, NK cells, microglia, lymphocytes, brain
RRID	AB_2783918, AB_2811689

References

References for CD11b Antibody, anti-mouse,
REAlease
^®

Publications

Pahl, H. L. et al. (1992) Characterization of the myeloid-specific CD11b promoter. Blood 79(4): 865-870
Lebson, L. et al. (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J. Neurosci. 30(29): 9651-9658
Liu, T. et al. (2014)
Gr-1
⁺
CD11b
⁺
cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation.
Sci. Rep. 4: 4833

CD11b Antibody, anti-mouse,
REAlease
^®

CD11b Antibody, anti-mouse,
REAlease
^®

Flow cytometry

Specifications for CD11b Antibody, anti-mouse,
REAlease
^®

Overview

Alternative names

Detailed product information

Technical specifications

References for CD11b Antibody, anti-mouse,
REAlease
^®

Publications

Applications

Specifications

Specifications for CD11b Antibody, anti-mouse,
REAlease
^®

Overview

Alternative names

Detailed product information

Technical specifications

References

References for CD11b Antibody, anti-mouse,
REAlease
^®

Publications

Shop

Careers

About Miltenyi Biotec

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CD11b Antibody, anti-mouse, REAlease®

CD11b Antibody, anti-mouse, REAlease®

Flow cytometry

Specifications for CD11b Antibody, anti-mouse, REAlease®

Overview

Alternative names

Detailed product information

Technical specifications

References for CD11b Antibody, anti-mouse, REAlease®

Publications

Applications

Specifications

Specifications for CD11b Antibody, anti-mouse, REAlease®

Overview

Alternative names

Detailed product information

Technical specifications

References

References for CD11b Antibody, anti-mouse, REAlease®

Publications

Shop

Careers

About Miltenyi Biotec

CD11b Antibody, anti-mouse,
REAlease
^®

CD11b Antibody, anti-mouse,
REAlease
^®

Specifications for CD11b Antibody, anti-mouse,
REAlease
^®

References for CD11b Antibody, anti-mouse,
REAlease
^®

Specifications for CD11b Antibody, anti-mouse,
REAlease
^®

References for CD11b Antibody, anti-mouse,
REAlease
^®