Clone:
REA1321
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
integrin αM, Mac-1 α, Integrin alpha-M, CR3A

Specifications for CD11b Antibody, anti-human, REAfinity™

Overview

Clone REA1321 recognizes the human CD11b antigen (Mac-1 α; integrin αM chain), which is part of the CD11b/CD18 heterodimer (Mac-1 α, Mβ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells. It is reported, that CD11b is able to control myeloid cell polarization and tumor growth. Furthermore, it induces cytotoxicity in ovarian cancer cells and is considered to be used as a therapeutic target. It is weakly expressed on natural killer (NK) cells and some activated lymphocytes as well as on microglia in the brain. Additional information: Clone REA1321 displays negligible binding to Fc receptors.

Alternative names

integrin αM, Mac-1 α, Integrin alpha-M, CR3A

Detailed product information

Technical specifications

CloneREA1321
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD11b
Alternative names of antigenintegrin αM, Mac-1 α, Integrin alpha-M, CR3A
Distribution of antigenmyeloid cells, NK cells, other, tonsil
RRIDAB_2904691

Resources for CD11b Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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