Clone:
REA1104
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
Calponin-1, Basic calponin, Calponin H1 smooth muscle, Calponin 1, CNN1

Specifications for Calponin Antibody, anti-human, REAfinity™

Overview

Clone REA1104 recognizes the human and rat Calponin, a filament-associated calcium binding protein also known as Calponin-1 or CNN1. Calponin is strongly expressed in osteoblasts and smooth muscle cells. It binds several actin binding proteins and phospholipids e.g. actin, calmodulin, troponin C and tropomyosin. Calponin plays a role in the actin-myosin interaction and inhibits the ATPase activity of myosin in smooth muscle.
Additional information: Clone REA1104 displays negligible binding to Fc receptors.

Alternative names

Calponin-1, Basic calponin, Calponin H1 smooth muscle, Calponin 1, CNN1

Detailed product information

Technical specifications

CloneREA1104
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, rat
Cross-reactivityrat
AntigenCalponin
Alternative names of antigenCalponin-1, Basic calponin, Calponin H1 smooth muscle, Calponin 1, CNN1
Molecular mass of antigen [kDa]33
Distribution of antigenosteoblasts, smooth muscle
Entrez Gene ID1264
RRIDAB_2876985, AB_2876921, AB_2876965

References for Calponin Antibody, anti-human, REAfinity™

Publications

  1. Applegate, D. et al. (1994) Cloning and expression of a novel acidic calponin isoform from rat aortic vascular smooth muscle. J. Biol. Chem. 269(14): 10683-10690
  2. Fujii, T. et al. (1995) Interaction of calponin with phospholipids. J. Biochem. 117(5): 999-1003
  3. Sasaki, Y. et al. (2002) Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosis. Cancer 94(6): 1777-1786

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