Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Alternative names:
connecting peptide, Proinsulin, Insulin

Specifications for C-peptide Antibody, anti-human, REAdye_lease™


Clone REAL1250 is an antibody fragment derived from the full C-peptide antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1250 recognizes the C-peptide polypeptide, also known as connecting peptide, that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. The signal activates Ca2
-dependent intracellular signaling pathways such as MAPK, PLCγ, and PKC, leading to upregulation of a range of transcription factors as well as eNOS and Na
ATPase activities. C-peptide also has been reported to have anti-inflammatory effects as well as aid repair of smooth muscle cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

connecting peptide, Proinsulin, Insulin

Detailed product information

Technical specifications

Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Alternative names of antigenconnecting peptide, Proinsulin, Insulin
RRIDAB_2905174, AB_2905175

Resources for C-peptide Antibody, anti-human, REAdye_lease™


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References for C-peptide Antibody, anti-human, REAdye_lease™


  1. Grunberger, G. et al. (2004) The C-peptide signaling. Exp Diabesity Res. 5(1): 25-26
  2. Pujia, A. et al. (2017) An update on the potential role of C-peptide in diabetes and osteoporosis. Endocrine 58(3): 408-412
  3. Yaribeygi, H. et al. (2019) The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sci. 237: 116950

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