Clone:
REAL1250
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
connecting peptide, Proinsulin, Insulin

Specifications for C-peptide Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1250 is an antibody fragment derived from the full C-peptide antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1250 recognizes the C-peptide polypeptide, also known as connecting peptide, that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. The signal activates Ca2
+
-dependent intracellular signaling pathways such as MAPK, PLCγ, and PKC, leading to upregulation of a range of transcription factors as well as eNOS and Na
+
K
+
ATPase activities. C-peptide also has been reported to have anti-inflammatory effects as well as aid repair of smooth muscle cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

connecting peptide, Proinsulin, Insulin

Detailed product information

Technical specifications

CloneREAL1250
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenC-peptide
Alternative names of antigenconnecting peptide, Proinsulin, Insulin
RRIDAB_2905174, AB_2905175

Resources for C-peptide Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for C-peptide Antibody, anti-human, REAdye_lease™

Publications

  1. Grunberger, G. et al. (2004) The C-peptide signaling. Exp Diabesity Res. 5(1): 25-26
  2. Pujia, A. et al. (2017) An update on the potential role of C-peptide in diabetes and osteoporosis. Endocrine 58(3): 408-412
  3. Yaribeygi, H. et al. (2019) The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sci. 237: 116950

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