Clone REA373 recognizes the human and mouse Bcl-6 antigen, a member of the BTB-zinc finger family of proteins. Bcl-6 is a transcriptional repressor, expressed in germinal center T and B cells and in primary immature dendritic cells. It plays critical functions in various cell types within the adaptive and innate compartments of the immune system. Bcl-6 is highly up-regulated in B cells after T cell–dependent antigenic challenge, and is required for formation of germinal centers within which B cells undergo immunoglobulin affinity maturation. It also plays an important role in macrophages, where it mediates a dampening effect on inflammatory signaling through repression of chemokine expression and NF-κB target genes.

Additional information: Clone REA373 displays negligible binding to Fc receptors.