Clone REAL717 is an antibody fragment derived from the full ACPP antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL717 recognizes the human ACPP (acid phosphatase, prostate), also known as PAP (prostatic acid phosphatase. ACPP is a non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions. ACPP has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Isoform 2 of ACPP acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. It also generates adenosine from AMP which acts as a pain suppressor.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
