CDw198 (CCR8) antibodies, mouse

CDw198 (CCR8) antibodies, mouse

Clone: REA921 | Dilution: 1:50
Clone REA921 recognizes the mouse CDw198 antigen, also known as C-C chemokine receptor type 8 (CCR8). CDw198, a G-protein coupled receptor with seven transmembrane regions, is a member of the beta chemokine receptor family, which binds to the T cell activation gene 3 (TCA-3) and CCL1. CDw198 is primarily found in thymus. It is expressed in activated Tʜ2-polarized cells and NK1.1
+
CD4
+
T cells, but also in subsets of monocytes, macrophages, and monocyte-derived dendritic cells. CDw198 plays a role in migration of various cell types into inflammatory sites.
Additional information: Clone REA921 displays negligible binding to Fc receptors.

Alternative names

CCR8, CCR-8, CC-CKR-8

Technical specifications

  • Antigen: CDw198 (CCR8)
  • Clone: REA921
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CCR8, CCR-8, CC-CKR-8
  • Entrez Gene ID: 12776
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: thymocytes, dendritic cells, macrophages, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, VioBright 515
  • Selected references

    1. Goya, I. et al. (1998) Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J. Immunol. 160(4): 1975-1981
    2. Zingoni, A. et al. (1998) The chemokine receptor CCR8 is preferentially expressed in Tʜ2 but not Tʜ1 cells. J. Immunol. 161(2): 547-551
    3. Islam, S. A. et al. (2011)
      Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5
      +
      Tʜ2 cells.
      Nat. Immunol. 12(2): 167-177
Product options: 5
130-115-377

CDw198 (CCR8)-PE, mouse

30 µg in 200 µL (1)
EUR 85,00 
130-115-378

CDw198 (CCR8)-APC, mouse

30 µg in 200 µL (1)
EUR 85,00 
130-119-922

CDw198 (CCR8)-PE-Vio615, mouse

30 µg in 200 µL (1)
EUR 110,00 
130-119-923

CDw198 (CCR8)-PE-Vio770, mouse

30 µg in 200 µL (1)
EUR 110,00 
130-115-379

CDw198 (CCR8)-VioBright 515, mouse

30 µg in 200 µL (1)
EUR 155,00