CD44 antibodies, human

CD44 antibodies, human

Clone: REA690 | Dilution: 1:50
Clone REA690 recognizes the CD44 antigen. CD44 is a marker for many types of cancer stem cells (CSCs), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.
Additional information: Clone REA690 displays negligible binding to Fc receptors.

Alternative names

CD44s, EMCR III, H-CAM, Pgp-1

Technical specifications

  • Antigen: CD44
  • Clone: REA690
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD44s, EMCR III, H-CAM, Pgp-1
  • Entrez Gene ID: 960
  • Molecular mass of antigen [kDa]: 79
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: bone marrow, cancer stem cells, CNS cells, endothelial cells, epithelial cells, kidney, leukocytes, lymphocytes, mesenchymal stem cells, myeloid cells, plasma cells, ES and iPS cells, red blood cells, skeletal muscle, skin, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin, PerCP-Vio700
  • Selected references

    1. Al-Hajj, M. et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100: 3983-3988
    2. Dalerba, P. et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 104: 10158-10163
    3. Collins, A. T. et al. (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65: 10946-10951
    4. Aruffo, A. et al. (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313
    5. Patrawala, L. et al. (2006)
      Highly purified CD44
      +
      prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells.
      Oncogene 25: 1696-1708
    6. Wang, L. et al. (2013) Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy. Int. J. Biol. Sci. 9(5): 472-479
Product options: 16
130-113-903

CD44-FITC, human

for 30
tests
(1)
EUR 100,00 
130-113-341

CD44-FITC, human

for 100
tests
(1)
EUR 240,00 
130-113-904

CD44-PE, human

for 30
tests
(1)
EUR 115,00 
130-113-342

CD44-PE, human

for 100
tests
(1)
EUR 285,00 
130-113-900

CD44-APC, human

for 30
tests
(1)
EUR 115,00 
130-113-338

CD44-APC, human

for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 125,00 
for 100
tests
(1)
EUR 300,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 

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