Clone REA256 recognizes the CD32 antigen, a 40 kDa polymorphic transmembrane glycoprotein also known as low affinity immunoglobulin gamma Fc region receptor II (FcγRII or FCRII). CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. Rat CD32 is expressed by B lymphocytes, myeloid cells, some lymphocytes in the thymic medulla, and cells which appear homologous to plasmacytoid dendritic cells. It mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to aggregated IgG and immune complexes and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body.
Additional information: Clone REA256 displays negligible binding to Fc receptors.