CD295 (LEPR) antibodies, human

CD295 (LEPR) antibodies, human

Clone: REA361 | Dilution: 1:11
Clone REA361 recognizes the human CD295 antigen, a single-pass type I membrane protein which is also known as leptin receptor (LEPR). CD295 is a member of the type I cytokine receptor family which acts through Janus kinases and signal transducers and activators of transcription. It is predominantly expressed in the central nervous system and in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. CD295 is the receptor for leptin, a peptide hormone which is secreted by the adipose tissue at levels roughly proportional to fat content. Leptin communicates the repletion of peripheral energy stores to the brain, suppressing feeding and permitting/promoting energy expenditure via a variety of neuroendocrine and autonomic mechanisms.
Additional information: Clone REA361 displays negligible binding to Fc receptors.

Alternative names

LEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219)

Technical specifications

  • Antigen: CD295 (LEPR)
  • Clone: REA361
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219)
  • Entrez Gene ID: 3953
  • Molecular mass of antigen [kDa]: 130
  • Distribution of antigen: brain, lung, kidney, hematopoietic stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Tartaglia, L. A. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83(7): 1263-1271
    2. Cioffi, J. A. et al. (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2(5): 585-589
    3. Villanueva, E. C. et al. (2008) Leptin receptor signaling and the regulation of mammalian physiology. Int. J. Obes. (Lond.) 32(7): 8-12
Product options: 12
130-105-213

CD295 (LEPR)-VioBright FITC, human

for 30
tests
(1)
EUR 130,00 
130-105-154

CD295 (LEPR)-VioBright FITC, human

for 100
tests
(1)
EUR 310,00 
130-105-210

CD295 (LEPR)-PE, human

for 30
tests
(1)
EUR 115,00 
130-105-151

CD295 (LEPR)-PE, human

for 100
tests
(1)
EUR 285,00 
130-105-211

CD295 (LEPR)-APC, human

for 30
tests
(1)
EUR 115,00 
130-105-152

CD295 (LEPR)-APC, human

for 100
tests
(1)
EUR 285,00 
130-105-212

CD295 (LEPR)-PE-Vio770, human

for 30
tests
(1)
EUR 130,00 
130-105-153

CD295 (LEPR)-PE-Vio770, human

for 100
tests
(1)
EUR 310,00 
130-105-214

CD295 (LEPR)-APC-Vio770, human

for 30
tests
(1)
EUR 130,00 
130-105-155

CD295 (LEPR)-APC-Vio770, human

for 100
tests
(1)
EUR 310,00 
130-105-209

CD295 (LEPR)-Biotin, human

for 30
tests
(1)
EUR 100,00 
130-105-150

CD295 (LEPR)-Biotin, human

for 100
tests
(1)
EUR 240,00 

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