CD279 (PD1) antibodies, human

CD279 (PD1) antibodies, human

Clone: REA1165 | Dilution: 1:50
Clone REA1165 recognizes the human CD279 antigen, also known as programmed death-1 (PD-1) or PD1. CD279 is a 55 kDa transmembran protein belonging to the CD28/CTLA-4 family. It is expressed on T cells, B cells, NK cells, activated myeloid cells, and dendritic cells. CD279 is not expressed on naive T cells but induced after activation and expressed on late, differentiated T cells. The ligands PD-L1 (CD274, also knwon as B7-H1) and PD-L2 (CD273, also known as B7-DC) belong to the B7 immunglobulin superfamily. PD-1 and its ligands mediate inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology.
Additional information: Clone REA1165 displays negligible binding to Fc receptors.

Alternative names

PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1

Technical specifications

  • Antigen: CD279 (PD1)
  • Clone: REA1165
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
  • Entrez Gene ID: 5133
  • Molecular mass of antigen [kDa]: 29
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, monocytes, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, VioBright 515, Biotin
  • Selected references

    1. Okazaki, T. and Honjo, T. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 19: 813-824
    2. Keir, M. E. et al. (2008) PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26: 677-704
    3. Serriari, N.-E. et al. (2010) B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J. Immunol. 185: 3140-3148
    4. Fife, B. T. et al. (2011) The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann. N. Y. Acad. Sci. 1217: 45-59
Product options: 10
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 285,00 
for 30
tests
(1)
EUR 130,00 
for 100
tests
(1)
EUR 310,00 
for 30
tests
(1)
EUR 165,00 
for 100
tests
(1)
EUR 390,00 
for 30
tests
(1)
EUR 100,00 
for 100
tests
(1)
EUR 240,00 

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